产品目录

分子量：Approximately 7.8kDa,a single non-glycosylated polypeptide chain containing 72 amino acid residues.
储存条件：冷冻（-20℃）

概述

Murine CXCL1,also known as KC,is belonging to the CXC chemokine family.It is encoded by the GRO gene now designated CXCL1.The gene for CXCL1 was initially discovered in mouse fibroblasts by plateletderived growth factor.KC is member of the intercrine alpha(chemokine C-X-C)subfamily of chemokines.It is secreted by human melanoma cells,and also expressed by macrophages,neutrophils and epithelial cells.The functional receptor for CXCL1 has been identified as CXCR2.CXCL1 has chemotactic activity for neutrophils,and plays a role in inflammation and wound healing.Amino acid sequence of murine CXCL1 is approximately 60%identical to the human CXCL1.KC was found to be involved in monocyte arrest on atherosclerotic endothelium and may also play a pathophysiological role in Alzheimer’s disease.

使用说明

This material is offered by Biorab Biotech for research,laboratory or further evaluation purposes.NOT FOR HUMAN USE.

技术规格

外观	Sterile Filtered White lyophilized(freeze-dried)powder.
纯度	＞97%by SDS-PAGE and HPLC analyses.
来源	Escherichia coli.
生物活性	Fully biologically active when compared to standard.The biological activity determined by a chemotaxis bioassay using human peripheral blood neutrophils is in a concentration range of 10-100ng/ml.
成分	Lyophilized from a 0.2μmfiltered concentrated solution in PBS,pH 7.4.
内毒素	Less than 1 EU/μg of rMuKC/CXCL1 as determined by LAL method.
复溶	We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom.Reconstitute in sterile distilled water or aqueous buffer containing 0.1%BSA to a concentration of 0.1-1.0mg/mL.Stock solutions should be apportioned into working aliquots and stored at ≤ -20?C.Further dilutions should be made in appropriate buffered solutions.
氨基酸序列	APIANELRCQ CLQTMAGIHL KNIQSLKVLP SGPHCTQTEV IATLKNGREA CLDPEAPLVQ KIVQKMLKGV PK

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